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Department of Psychiatry

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Nicola Filippini DPhil (Oxon)

Post-doc Research Fellow
Nicola Filippini is a postdoctoral researcher (The HDH Wills 1965 Charitable Trust) in the Department of Psychiatry and FMRIB Centre at the University of Oxford. He finished his DPhil program in 2010 with a thesis entitled “Brain structure, function and connectivity associated with APOE genotype: what changes when?” His main interests are Alzheimer’s disease and genetic risk factors that he explored using a wide range of neuroimaging techniques. In particular, functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI) and structural MRI (sMRI) and arterial spin labelling (ASL). He is currently involved in a series of projects that aim: 1) to define the effect of APOE on the brain; 2) to identify the biological meaning of resting state networks; 3) to define MRI markers for amyotrophic lateral sclerosis. See DPhil Thesis "Brain structure, function and connectivity associated with APOE genotype" on left <--

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Recent Publications

Contact address FMRIB Centre University of Oxford Nuffield Department of Clinical Neurosciences John Radcliffe Hospital Headington Oxford OX3 9DU
Department Department of Psychiatry
Nicola Filippini

Dr Nicola Filippini

Biography

A) First author or **joint first co-authorship

9) Filippini, N, Nickerson, LD, Beckmann, CF, Ebmeier, KP, Frisoni, GB, Matthews, PM, Smith, SM, and Mackay, CE (2011). Age-related adaptations of brain function during a memory task are also present at rest. NeuroImage (in press).

8) Douaud G**, Filippini N**, Knight S, Talbot K, Turner MR. Integration of structural and functional MRI in amyotrophic lateral sclerosis. Brain 2011 Nov 10. [Epub ahead of print].

7) Heise V**, Filippini N**, Ebmeier KP, Mackay CE. The APOE ε4 allele modulates brain white matter integrity in healthy adults. Molecular Psychiatry. 2011 Sep;16(9):908-916.

6) Nicola Filippini, Klaus P Ebmeier, Bradley J MacIntosh, Aaron J Trachtenberg, Giovanni B Frisoni, Gordon K Wilcock, Christian F Beckmann, Stephen M Smith, Paul M Matthews, Clare E Mackay. Differential effects of the APOE genotype on brain function across the lifespan. Neuroimage. 2011 Jan 1;54(1):602-10.

5) Filippini N**, Douaud G**, Mackay CE, Knight S, Talbot K, Turner MR. Corpus callosum involvement is a consistent feature of amyotrophic lateral sclerosis. Neurology. 2010 Nov 2;75(18):1645-52.

4) Filippini N, MacIntosh BJ, Hough MG, Goodwin GM, Frisoni GB, Smith SM, Matthews PM, Beckmann CF, Mackay CE. Distinct patterns of brain activity in young carriers of the APOE-ε4 allele. Proc Natl Acad Sci U S A. 2009, Apr 28;106(17):7209-7214.

3) Filippini N, Zarei M, Beckmann CF, Galluzzi S, Borsci G, Testa C, Bonetti M, Beltramello A, Ghidoni R, Benussi L, Binetti G, Frisoni GB. Regional Atrophy of Transcallosal Prefrontal Connections in Cognitively Normal APOE ε4 Carriers. JMRI, 2009 May;29(5):1021-6.

2) Nicola Filippini**, Anil Rao**, Sally Wetten, Rachel A. Gibson, Michael Borrie, Danilo Guzman, Andrew Kertesz, Inge Loy-English, Julie Williams, Thomas Nichols, Brandon Whitcher, Paul M. Matthews. Anatomically-distinct genetic associations of APOE ε4 allele load with regional cortical atrophy in Alzheimer’s disease. NeuroImage, 2009 Feb 1;44(3):724-8.

1) Filippini N, Scassellati C, Boccardi M, Pievani M, Testa C, Bocchio-Chiavetto L, Frisoni GB, Gennarelli M. Influence of serotonin receptor 2A His452Tyr polymorphism on brain temporal structures analysed by a MRI study. Eur J Hum Genet, 2006 Apr;14(4):443-9.

B) Subsidiary co-authorship

12) Aaron J Trachtenberg, Nicola Filippini, Klaus P Ebmeier, Steve M Smith, Fredrik Karpe, Clare E Mackay. The effects of APOE on the functional architecture of the resting brain. Neuroimage. Accepted

11) Sbardella E, Tomassini V, Stromillo ML, Filippini N, Battaglini M, Ruggieri S, Ausili Cefaro L, Raz E, Gasperini C, Pantano P, Pozzilli C, De Stefano N. Pronounced focal and diffuse brain damage predicts short-term disease evolution in patients with clinically isolated syndrome suggestive of multiple sclerosis. Multiple Sclerosis. Accepted.

10) Ebmeier KP, Filippini N, Heise V, Sexton CE. Other magnetic resonance imaging techniques. International Psychogeriatrics. 2011 Sep;23 Suppl 2:S50-7.

9) McCabe C, Mishor Z, Filippini N, Cowen PJ, Taylor MJ, Harmer CJ. SSRI administration reduces resting state functional connectivity in dorso-medial prefrontal cortex. Mol Psychiatry. In press.

8) Trachtenberg AJ, Filippini N, Cheeseman J, Duff EP, Neville MJ, Ebmeier KP, Karpe F, Mackay CE. The effects of APOE on brain activity do not reflect Alzheimer's disease risk. Neurobiology of Aging. In press.

7) Agostini A, Filippini N, Cevolani D, Agati R, Leoni C, Tambasco R, Calabrese C, Rizzello F, Gionchetti P, Ercolani M, Leonardi M, Campieri M. Brain functional changes in patients with Ulcerative Colitis: an fMRI study on emotional processing. Inflammatory Bowel Diseases. 2011 Aug;17(8):1769-77

6) Inkster B, Rao AW, Ridler K, Filippini N, Whitcher B, Nichols TE, Wetten S, Gibson RA, Borrie M, Kertesz A, Guzman DA, Loy-English I, Williams J, Saemann PG, Auer DP, Holsboer F, Tozzi F, Muglia P, Merlo-Pich E, Matthews PM. Genetic variation in GOLM1 and prefrontal cortical volume in Alzheimer's disease. Neurobiology of Aging. In press.

5) Sexton CE, Kalu UG, Filippini N, Mackay CE, Ebmeier KE. A meta-analysis of diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging. In press.

4) Gwilym S, Filippini N, Douaud G, Carr A, Tracey I. Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty. Arthritis & Rheumatism. 2010 Oct;62(10):2930-40

3) Trachtenberg AJ, Filippini N, Mackay CE. The effects of APOE-ε4 on the BOLD response. Neurobiology of Aging. In press.

2) MacIntosh BJ, Filippini N, Chappell MA, Woolrich MW, Mackay CE, Jezzard P. Assessment of arterial arrival times derived from multiple inversion time pulsed arterial spin labeling MRI. Magn Res Med. 2010, Mar;63(3):641-7.

1) Smith S, Fox P, Miller K, Glahn D, Fox P, Mackay C, Filippini N, Watkins K, Toro R, Laird A, Beckmann C. Correspondence of the brain's functional architecture during activation and rest. Proc Natl Acad Sci U S A. 2009, Aug 4; 106(31):13040-5.

C) Book chapters

2) Klaus P. Ebmeier, Nicola Filippini and Clare E. Mackay (2010). Chapter 11: Brain function and connectivity in dementia. In: DEMENTIA 4th Edition; Editors David Ames, Alistair Burns and John T. O’Brien.

1) Frisoni G, Filippini N. (2007) Quantitative and functional MRI techniques, in Herholz K, Perani D, Morris CM (Eds.), The Dementias: Early Diagnosis and Evaluation.

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