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Publications
2008
Sartorius LJ, Weinberger DR, Hyde T, Harrison PJ, Kleinman JE, Lipska BK (2008) Expression of a GRM3 splice variant is increased in the dorsolateral prefrontal cortex of individuals carrying a schizophrenia risk SNP. Neuropsychopharmacology (in press)
Tunbridge EM, Harrison PJ, Walden DR, Refsum H, Johnston C, Smith AD (2008) Polymorphisms in the catechol-O-methyltransferase (COMT) gene influence plasma total homocysteine levels. American Journal of Medical Genetics B: Neuropsychiatric Genetics (published on-line, 11 January 2008; doi:10.1002/ajmg.b.30700)
Harrison PJ (2008) Metabotropic glutamate receptor agonists for schizophrenia. British Journal of Psychiatry 192:
Harrison PJ, Lyon L, Sartorius LJ, Burnet PWJ, Lane TA (2008) Metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function, and involvement in schizophrenia. Journal of Psychopharmacology (in press, 5.11.07)
Harrison PJ (2008) Schizophrenia genes: searching for common features, functions, and mechanisms. In Cortical Deficits in Schizophrenia: From Genes to Function, ed. O’Donnell P. Springer, Norwell MA, pp.1-16.
2007
Verrall L, Walker M, Rawlins N, Bunzel I, Kew JNC, Harrison PJ, Burnet PWJ (2007) D-amino acid oxidase and serine racemase in human brain: normal distribution and altered expression in schizophrenia. European Journal of Neuroscience 26 1657-1669 [open access]
Eastwood SL, Lyon L, George L, Job D, Andrieux A, Harrison PJ (2007) Altered expression of synaptic protein mRNAs in STOP (MAP-6) mutant mice. Journal of Psychopharmacology 21 635-644.
Eastwood SL, Harrison PJ (2007) Netrin G1 and G2 expression in the temporal lobe: effects of schizophrenia, bipolar disorder, and genetic polymorphisms. Neuropsychopharmacology (epub 16 May 2007; doi:10:1038/sj.npp1301457
Tan W, Wang Y, Gold B, Chen J, Dean M, Harrison PJ, Weinberger DR, Law AJ (2007) Molecular cloning of a brain-specific, developmentally regulated Neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia. Journal of Biological Chemistry 282 24343-24351.
Tunbridge EM, Lane TA, Harrison PJ (2007) Expression of multiple catechol-o-methyltransferase (COMT) mRNA variants in human brain. American Journal of Medical Genetics B Neuropsychiatric Genetics 144 834-839. [open access]
Pooley EC, Fineberg N, Harrison PJ (2007) The met158 allele of COMT is associated with obsessive-compulsive disorder in men: case control study and meta-analysis. Molecular Psychiatry 12 556-561
Tunbridge EM, Weickert CS, Kleinman JE, Herman MM, Chen J, Kolachana BS, Harrison PJ, Weinberger DR (2007) Catechol-o-methyltransferase enzyme activity and protein expression in human prefrontal cortex across the postnatal lifespan. Cerebral Cortex 17 1206-1212
Harrison PJ, Tunbridge EM. Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders. Neuropsychopharmacology (NPP-07-0208; in press, 12.7.07)
Harrison PJ (2007) Schizophrenia susceptibility genes and neurodevelopment. Biological Psychiatry 61 1119-1120
Harrison PJ (2007) Schizophrenia susceptibility genes and their neurodevelopmental implications: focus on neuregulin 1. In Cortical Development: Genes and Genetic Abnormalities. Novartis Foundation Symposium 288. eds. Bock G, Goode J. Wiley, pp246-259.
2006
Eastwood SL, Weickert CS, Webster MJ, Herman MM, Kleinman JE, Harrison PJ. Synaptophysin protein and mRNA expression in the human hippocampal formation from birth to old age. Hippocampus 16 645-654
Law AJ, Lipska BK, Weickert CS, Hyde TM, Straub RE, Hashimoto R, Harrison PJ, Kleinman JE, Weinberger DR (2006) Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5’ SNPs associated with the disease. Proceedings of the National Academy of Sciences USA 103 6747-6752
Harrison PJ, West V (2006) Six degrees of separation: on the prior probability that schizophrenia susceptibility genes converge upon synapses, glutamate, and NMDA receptors. Molecular Psychiatry 11 981-983
Law AJ, Lipska BK, Weickert CS, Hyde TM, Straub RE, Hashimoto R, Harrison PJ, Kleinman JE, Weinberger DR (2006) Neuregulin 1 (NRG1) transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease. Proceedings of the National Acadamy of Sciences USA (in press)
Sartorius LJ, Nagappan G, Lipska BK, Lu B, Sei Y, Ren-Patterson R, Li Z, Weinberger DR, Harrison PJ (2006) Alternative splicing of human metabotropic glutamate receptor 3. Journal of Neurochemistry 96 1139-1148
Eastwood SL, Harrison PJ (2006) Cellular basis of decreased cortical reelin expression in schizophrenia. American Journal of Psychiatry 163 540-542
Cullen TJ, Walker M, Eastwood SL, Esiri MM, Harrison PJ, Crow TJ (2006) Anomalies of asymmetry of neuronal density and structure in dorsolateral prefrontal cortex in schizophrenia. British Journal of Psychiatry 188 26-31
Tunbridge EM, Weinberger DR, Harrison PJ (2006) A novel protein isoform of catechol O-methyltransferase (COMT): brain expression analysis in schizophrenia and bipolar disorder and effect of Val158Met genotype. Molecular Psychiatry 11 116-117
Peer-reviewed reviews and editorials
Harrison PJ, Law AJ (2006). Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology. Biological Psychiatry (in press)
Tunbridge EM, Harrison PJ, Weinberger DR (2006) Catechol-o-methyltransferase, cognition and psychosis: Val158Met and beyond. Biological Psychiatry (in press)
Books
Gelder MG, Harrison PJ, Cowen PJ (2006) Shorter Oxford Textbook of Psychiatry, 5th edn. Oxford, Oxford University Press.
2005
Data
papers
Eastwood SL, Saleh T, Harrison PJ (2005) Differential expression of calcineurin
A subunit isoforms during hippocampal and cerebellar development. European
Journal of Neuroscience 22 3017-3024
Eastwood SL, Harrison PJ (2005) Interstitial white matter neuron density in the
dorsolateral prefrontal cortex and parahippocampal gyrus in schizophrenia Schizophrenia
Research 79 181-188
Sodhi MS, Airey DC, Lambert W, Burnet PWJ, Harrison PJ, Sanders-Bush E (2005) A
rapid new assay to detect RNA editing reveals antipsychotic-induced changes in
5-HT2C transcripts. Molecular Psychiatry 68 771-719
Syed A, Chatfield M, Matthews F, Harrison P, Brayne C, Esiri MM, for the
Neuropathology group in MRC-CFAS (2005) Depression in the elderly: pathological
study of raphe and locus cerulus Neuropathology and Applied Neurobiology 31
405-413
Eastwood SL, Harrison PJ (2005) Decreased vesicular glutamate transporter 1
(VGLUT1) and complexin II expression in schizophrenia: further evidence for a
synaptic pathology affecting glutamatergic neurons. Schizophrenia Research 73
159-172
Eastwood SL, Burnet PWJ, Harrison PJ (2005) Decreased hippocampal expression of
the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia Biological
Psychiatry 57 702-710
Peer-reviewed reviews and editorials
Harrison PJ, Weinberger DR (2005) Schizophrenia genes, gene expression and neuropathology: on the matter of their convergence. Molecular Psychiatry 10 40-68
Owen
MJ, O'Donovan MC, Harrison PJ (2005) Schizophrenia: a genetic disorder of the
synapse? BMJ 330 158-159
Harrison PJ (2005) Weight gain with antipsychotic drugs: the role of the 5-HT2C
receptor (HTR2C) and other genes Pharmacogenetics and Genomics 15
193-194
Chapters
Harrison PJ (2005) Is any of this real? The word from the grave. In Bipolar
Disorder: The upswing in research and treatment, eds McDonald C, Schulze K,
Murray RM, Tohen M. London, Taylor and Francis, pp59-68
Harrison PJ (2005) Neuropathology of schizophrenia. Psychiatry 4 (10)
18-21
Books
Harrison PJ, Geddes J, Sharpe M (2005) Lecture Notes: Psychiatry, 9th
edn, pp224. Oxford,
Blackwell Science.
2004
Data papers
Law AJ, Weickert CS, Hyde TM, Kleinman JE, Harrison PJ (2004) Neuregulin-1
(NRG1) messenger RNA and protein in the human brain: hippocampal formation,
prefrontal cortex, cerebellum and brainstem. Neuroscience 127 125-136
Tunbridge EM, Bannerman DM, Sharp T, Harrison PJ (2004) Catechol-O-methyltransferase
inhibition improves set shifting performance and elevates stimulated dopamine
release in the prefrontal cortex in the rat. Journal of Neuroscience 24
5331-5335
Law AJ, Weickert CS, Hyde TM, Kleinman JE, Harrison PJ (2004) Reduced
spinophilin but not MAP2 expression in the hippocampal formation in
schizophrenia and mood disorder: Molecular evidence for a pathology of
dendritic spines Americal Journal of Psychiatry 161 1848-1855
Gittins R, Harrison PJ (2004) A quantitative morphometric study of the human
anterior cingulate cortex Brain Research 1013 212-222
Gittins R, Harrison PJ (2004) Neuronal density, size and shape in the human
anteriour cingulate cortex: a comparison of Nissl and NeuN staining N Brain
Research Bulletin 63 55-6
Law AJ, Hutchinson LJ, Burnet PWJ, Harrison PJ (2004) Antipsychotics increase microtubule-associated protein 2 (MAP2) mRNA but not spinophilin mRNA in the rat hippocampus and cortex. Journal of Neuroscience Research 76 376-382.
Pooley EC, Fairburn CG, Cooper Z, Sodhi MS, Cowen PJ, Harrison PJ (2004) A 5-HT2C receptor promoter polymorphism (HTR2C -759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes. American Journal of Medical Genetics (Neuropsychiatric Genetics) 126B 124-127
Tunbridge E, Burnet PWJ, Sodhi MS, Harrison PJ (2004) Catechol-o-methyltransferase and proline dehydrogenase messenger RNA in the prefrontal cortex in schizophrenia, bipolar disorder and major depression. Synapse 51 112-118
Peer-reviewed reviews and editorials
Harrison PJ (2004) The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications Psychopharmacology 174 151-162
Burnet PWJ, Eastwood SL, Harrison PJ (2004) Laser-assisted microdissection: Methods for the molecular analysis of psychiatric disorders at a cellular resolution Biological Psychiatry 55 107-111
Chapters
Eastwood SL, (2004) The synaptic pathology of schizophrenia: is abberant neurodevelopment and plasticity to blame? Int Rev Neurobiol 59 47-72
Harrison PJ (2004) Schizophrenia and its dementia. In: The Neuropathology of Dementia, 2nd edition, eds. Esiri MM, Trojanowski JQ, Lee V-MY. Cambridge: Cambridge University Press, pp497-508.
2003
Data papers
Highley JR, Walker MA, Esiri MM, Crow TJ, Harrison PJ (2003) Lateralized reduction of medial and lateral pulvinar volumes in schizophrenia: a postmortem study. American Journal of Psychiatry (in press)
Harrison PJ, Freemantle N, Geddes JR (2003) Meta-analysis of brain weight in schizophrenia. Schizophrenia Research (in press)
Pooley EC, Hawton K, Houston K, Harrison PJ (2003) Deliberate self harm is associated with allelic variation of the tryptophan hydroxylase gene (A779C) but not with polymorphisms in five other serotonergic genes. Psychological Medicine (in press)
Peer-reviewed reviews and editorials
Fairburn CG, Harrison PJ (2003) Eating disorders [Seminar]. Lancet 361 407-416
Books
Harrison PJ, Lewis DA (2003) The neuropathology of schizophrenia. Chapter 17, in Schizophrenia, eds Hirsch SR, Weinberger DR. 2nd edition. Oxford: Blackwell Science, pp 306-317
Harrison PJ (2003) Schizophrenia and its dementia. In: The Neuropathology of Dementia, 2nd edition, eds. Esiri MM, Morris JH, Trojanowski JQ. Cambridge: Cambridge University Press (in press)
Harrison PJ, Gittins R (2003) The neuropathology of mood disorders. In Disorders of Brain and Mind, 2nd edition, eds. Ron M, Robbins T. Cambridge: Cambridge University Press (in press)
2002
Data Papers
Peer-reviewed reviews and editorials
Harrison PJ. (2002) The neuropathology of primary mood disorder. Brain 125 128-149.
Books
Harrison PJ (2002) Schizophrenia. In Diseases of the Nervous System: Clinical Neuroscience and Therapeutic Principles, 3rd edition, eds. Asbury AK, McKhann G, McDonald WI, Goadsby PJ, McArthur JC. Cambridge: Cambridge University Press, pp374-384.
Everall IP, Harrison PJ (2002) Methodological and stereological considerations in postmortem psychiatric brain research. In: The Postmortem Brain in Psychiatric Research, eds. Agam G, Everall IP, Belmaker RH. Boston, Kluwer Academic, pp 21-36.
2001
Data Papers
Eastwood SL, Burnet PWJ, Gittins R, Baker K, Harrison PJ (2001) Expression of serotonin 5-HT2A receptors in the human cerebellum, and alterations in schizophrenia. Synapse 42 104-114.
Harrison PJ, Eastwood SL (2001) Neuropathological studies of synaptic connectivity in the hippocampal formation in schizophrenia. Hippocampus 11 508-519.
Eastwood SL, Harrison PJ (2001) Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins. Brain Research Bulletin 55 569-578.
Eastwood SL, Cotter D, Harrison PJ (2001) Cerebellar synaptic protein expression in schizophrenia. Neuroscience 105 219-229.
Sodhi MS, Burnet PWJ, Makoff AJ, Kerwin RW, Harrison PJ (2001) RNA editing of the 5-HT2C receptor is reduced in schizophrenia. Molecular Psychiatry 6 373-379.
Burnet PWJ, Baker R, Lewis L, Pei Q, Sharp T, Harrison PJ (2001) Electroconvulsive shock increases tachykinin NK1 receptors, but not the encoding mRNA, in rat cortex. European Journal of Pharmacology 413, 213-219
Eastwood SL, Burnet PWJ, Gittins R, Baker K, Harrison PJ (2001) Expression of serotonin 5-HT2A receptors in the human cerebellum, and alterations in schizophrenia. Synapse 42 104-114
Eastwood SL, Cotter D, Harrison PJ (2001) Cerebellar synaptic protein expression in schizophrenia. Neuroscience 105 219-229
Eastwood SL, Harrison PJ (2001) Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins. Brain Research Bulletin 55(5) 569-78.
Harrison PJ, Eastwood SL (2001) Neuropathological studies of synaptic connectivity in the hippocampal formation in schizophrenia. Hippocampus 11(5) 508-19.
Law AJ, Deakin JFW (2001) Asymmetrical reductions of hippocampal NMDAR1 glutamate receptor mRNA in the psychoses. NeuroReport 12 2971-2974
Sharpley AL, Vassallo CM, Pooley EC, Harrison PJ, Cowen PJ (2001) Allelic variation in the 5-HT2C receptor (HTR2C) and the increase in slow wave sleep produced by olanzapine. Psychopharmacology 153 271-272
Sodhi MS, Burnet PWJ, Makoff AJ, Kerwin RW, Harrison PJ (2001) RNA editing of the 5-HT2C receptor is reduced in schizophrenia. Molecular Psychiatry 6 373-379
2000
Data Papers
Eastwood SL, Harrison PJ. Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. An immunoblotting study of synaptophysin, GAP-43 and the complexins and a review. Brain Research Bulletin 55 569-578
Geddes JR, Freemantle N, Harrison PJ, Bebbington P. Atypical antipsychotics in the treatment of schizophrenia - systematic overview and meta-regression analysis. BMJ 321(7273) 1371-6
Rabiner EA, Gunn RN, Castro ME, Sargent PA, Cowen PJ, Koepp MJ, Meyer JH, Bench CJ, Harrison PJ, Pazos A, Sharp T, Grasby PM (2000) b-blocker binding to human 5-HT1A receptor in vitro and in vivo: Implications for antidepressant therapy. Neuropsychopharmacology 23 285-293
Sisodiya SM, Heffernan J, Harrison PJ, Squier MV, Thom M (2000) Sulcogyral variation in NMDA receptor 2A/B subunit immunoreactivity in human brain. Neuroreport 11 2601-2606
Castro ME, Harrison PJ, Pazos A, Sharp T (2000) Affinity of (+)-pindolol, (-)-penbutolol and (-)-tertatolol for pre- and postsynaptic serotonin 5-HT1A receptors in human and rat brain. Journal of Neurochemistry 75 755-762
Whale R, Quested DJ, Laver D, Harrison PJ, Cowen PJ (2000) Serotonin transporter (5-HTT) promoter genotype influences the prolactin response to clomimpramine. Psychopharmacology 150 120-122
Eastwood SL, Harrison PJ (2000) Hippocampal synaptic pathology in schizophrenia, bipolar disorder and unipolar depression: a study of complexin mRNAs. Molecular Psychiatry 5 425-432
Eastwood SL, Burnet PWJ, Harrison PJ (2000) Expression of complexin I and II mRNAs and their regulation by antipsychotic drugs in the rat forebrain. Synapse 36 167-177
Eastwood SL, Cairns NJ, Harrison PJ (2000) Synaptophysin gene expression in schizophrenia. An investigation of synaptic pathology in the cerebral cortex. British Journal of Psychiatry 176 236-242
Burnet PWJ, Harrison PJ (2000) Substance P (NK1) receptors in the cingulate cortex in unipolar and bipolar mood disorder and schizophrenia. Biological Psychiatry 47 80-83
Peer-reviewed reviews and editorials
Harrison PJ. Dopamine and schizophrenia - proof at last? Lancet 356 958-959
Harrison PJ (2000) Neuropathological studies of bipolar disorder. Acta Neuropsychiatrica 12 98-100
Harrison PJ (2000) Post mortem studies in schizophrenia. Dialogues in Clinical Neuroscience 2 349-357
Harrison PJ (2000) The neurobiology of schizophrenia. In The New Oxford Textbook of Psychiatry, eds. Gelder MG, Andreasen NC, Lopez-Ibor J. Oxford University Press pp605-612
Books
Harrison PJ, Roberts GW (2000) The Neuropathology of Schizophrenia. Progress and interpretation. Oxford University Press, pp373.
1999
Data papers
Burnet PWJ, Sharp T, LeCorre SM, Harrison PJ (1999) Expression of 5-HT receptors and the 5-HT transporter in rat brain following electroconvulsive shock. Neuroscience Letters 277 79-82
Eastwood SL, Harrison PJ (1999) Detection and quantification of hippocampal synaptophysin mRNA in schizophrenia using autoclaved formalin-fixed paraffin-embedded sections. Neuroscience 93 99-106
Burnet PWJ, Smith KA, Cowen PJ, Fairburn CG, Harrison PJ (1999) Allelic variation of the 5-HT2C receptor (HTR2C) in bulimia nervosa and binge eating disorder. Psychiatric Genetics 9 101-104
Quested DJ, Whale R, Sharpley A, McGavin C, Crossland N, Harrison PJ, Cowen PJ (1999) Allelic variation in the 5-HT2C receptor (HTR2C) and functional responses to the 5-HT2C receptor agonist, m-chlorophenylpiperazine. Psychopharmacology 144:306-307
Peer-reviewed reviews and editorials
Harrison PJ (1999) Neurochemical alterations in schizophrenia affecting the putative receptor targets of atypical antipsychotics: Focus on dopamine (D1, D3, D4) and 5-HT2A receptors. British Journal of Psychiatry 174 (suppl. 38) 12-22
Harrison PJ (1999) Brains at risk of schizophrenia. Lancet 353 3-4
Harrison PJ (1999) The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain 122 593-624
Harrison PJ, East SZ.(1999) The serotonin 5-HT2A receptor and its gene in schizophrenia. Journal of Serotonin Research 5 1-6
Fairburn CG, Cowen PJ, Harrison PJ (1999) Twin studies and the aetiology of eating disorders. International Journal of Eating Disorders 26 349-358
Harrison PJ. (1999) Review: The neuropathological effects of antipsychotic drugs. Schizophrenia Research 40 87-99
1998
Data papers
Harrison PJ, Eastwood SL (1998) Schizophrenia: preferential involvement of excitatory neurons in medial temporal lobe. Lancet 352 1669-1673
Eastwood SL, Harrison PJ (1998) Hippocampal and cortical GAP-43 messenger RNA in schizophrenia. Neuroscience 86 437-448
Heffernan JM, Eastwood SL, Sanders M, Nagy Zs, McDonald B, Harrison PJ (1998) Temporal cortex synaptophysin mRNA is reduced in Alzheimer's disease and correlates negatively with the severity of dementia. Experimental Neurology 150 235-239
Books
Harrison PJ, Geddes JR, Sharpe M (1998) Lecture Notes on Psychiatry, 8th edition. Oxford: Blackwells, pp.192
1997
Data papers
Harrison PJ, Burnet PWJ, Falkai P, Bogerts B, Eastwood SL (1997) Gene expression and neuronal activity in schizophrenia: a study of polyadenylated mRNA in the hippocampal formation and cerebral cortex. Schizophrenia Research 26 93-102
Burnet PWJ, Harrison PJ, Goodwin GM,Battersby S, Ogilvie AD, Olesen J, Russell MB (1997) Allelic variation in the serotonin 5-HT2C receptor gene and migraine. Neuroreport 8 2651-2653
Le Corre SM, Burnet PWJ, Meller R, Sharp T, Harrison PJ (1997) Critical issues in the antisense inhibition of brain gene expression in vivo: experiences targetting the 5-HT1A receptor. Neurochemistry International 31 349-362
Eastwood SL, Heffernan J, Harrison PJ (1997) Chronic haloperidol treatment differentially affects the expression of synaptic and neuronal plasticity-associated genes. Molecular Psychiatry 2 322-329
Kouzmenko AP, Hayes WL, Pereira AM, Dean B, Burnet PWJ, Harrison PJ (1997) 5-HT2A receptor polymorphism and steady state receptor expression in schizophrenia. Lancet 349 1815
Zaidel DW, Esiri MM, Harrison PJ (1997) Neuronal size, shape, and orientation in the left and right hippocampus: investigations of normal asymmetries and alterations in schizophrenia. American Journal of Psychiatry 154 812-818
Burnet PWJ, Eastwood SL, Harrison PJ (1997) [3H]WAY-100635 for 5-HT1A receptor autoradiography in human brain: a comparison with [3H]8-OH-DPAT and demonstration of increased binding in the frontal cortex in schizophrenia. Neurochemistry International 30 565-574
Le Corre SM, Sharp T, Young AH, Harrison PJ (1997) Increase of 5-HT7 (serotonin-7) and 5-HT1A (serotonin-1A) receptor mRNA expression in rat hippocampus after adrenalectomy. Psychopharmacology 130 368-374
Porter RHP, Eastwood SL, Harrison PJ (1997) Distribution of kainate receptor mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia. Brain Research 751 217-231
Zaidel DW, Esiri MM, Harrison PJ (1997) The hippocampus in schizophrenia: lateralized increase in neuronal density and altered cytoarchitectural asymmetry. Psychological Medicine 27 703-713
Eastwood SL, Kerwin RW, Harrison PJ (1997) Immunoautoradiographic evidence for a loss of a-amino-3-hydroxy-5-methyl-4-isoxazole propionate-preferring non-N-methyl-D-aspartate glutamate receptors within the medial temporal lobe in schizophrenia. Biological Psychiatry 41 636-643
Eastwood SL, Burnet PWJ, Harrison PJ (1997) GluR2 glutamate receptor subunit flip and flop isoforms are decreased in the hippocampal formation in schizophrenia: a reverse transcriptase-polymerase chain reaction (RT-PCR) study. Molecular Brain Research 44 92-98
Peer-reviewed reviews and editorials
Geddes JR, Harrison PJ (1997) Evidence-based psychiatry: closing the gap between research and practice. British Journal of Psychiatry 171 220-225
Harrison PJ (1997) BSE and human prion disease. British Journal of Psychiatry 170 298-300
Harrison PJ (1997) Schizophrenia: a disorder of neurodevelopment? Current Opinion in Neurobiology 7 285-289
Harrison PJ, Burnet PWJ (1997) The 5-HT2A (serotonin2A) receptor gene in the aetiology, pathophysiology and pharmacotherapy of schizophrenia. Journal of Psychopharmacology 11 21-23
Books
Harrison PJ (1997) Schizophrenia and its dementia. In The Neuropathology of Dementia (eds Esiri MM, Morris JH). Cambridge University Press, Cambridge, pp 383-395.
Kerwin RW, Harrison PJ, Stefanis N (1997) Glutamate receptors and developmental anomaly in medial temporal lobe in schizophrenia. In Neurodevelopment and Adult Psychopathology (eds Keshavan MS, Murray RM). Cambridge University Press, Cambridge, pp 57-62.
1996
Data papers
Harrison PJ, Wighton-Benn WH, Heffernan JM, Sanders MW, Pearson RCA (1996) Amyloid precursor protein mRNAs in Alzheimer's disease. Neurodegeneration 5 409-415
Burnet PWJ, Eastwood SL, Harrison PJ (1996) 5-HT1A and 5-HT2A receptor mRNAs and binding site densities are differentially affected in schizophrenia. Neuropsychopharmacology 15 442-455
Eastwood SL, Porter RHP, Harrison PJ (1996) The effect of chronic haloperidol treatment on glutamate receptor subunit (GluR1, GluR2, NR1, KA1, KA2) mRNAs and glutamate binding protein mRNA in rat forebrain. Neuroscience Letters 212 163-166
McGowan S, Eastwood SL, Mead A, Burnet PWJ, Smith C, Flanigan TP, Harrison PJ (1996) Hippocampal and cortical G protein (Gs , Go and Gi2 ) mRNA expression after electroconvulsive shock or lithium carbonate treatment. European Journal of Pharmacology 306 249-255
Burnet PWJ, Chen CPL-H, McGowan S, Franklin M, Harrison PJ (1996) The effects of clozapine and haloperidol on serotonin-1A, -2A and -2C receptor gene expression and serotonin metabolism in the rat forebrain. Neuroscience 73 531-540
Porter RHP, Burnet PWJ, Eastwood SL, Harrison PJ (1996) Contrasting effects of electroconvulsive shock on mRNAs encoding the high affinity kainate receptor subunits (KA1 and KA2) and cyclophilin in rat brain. Brain Research 710 97-102
Peer-reveiwed reviews and editorials
Harrison PJ (1996) Advances in post mortem molecular neurochemistry and neuropathology: examples from schizophrenia research. British Medical Bulletin 52 527-538
Harrison PJ, Geddes JR (1996) Schizophrenia and the 5-HT2A receptor gene. Lancet 347 1274
1995
Data papers
Eastwood SL, Harrison PJ (1995) Decreased synaptophysin in the medial temporal lobe in schizophrenia demonstrated using immunoautoradiography. Neuroscience 69 339-343
Harrison PJ, Heath PR, Eastwood SL, Burnet PWJ, McDonald B, Pearson RCA (1995) The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies: selective mRNA vulnerability and comparison with their encoded proteins. Neuroscience Letters 200 151-154
Burnet PWJ, Harrison PJ (1995) Genetic variation of the 5HT2A receptor and response to clozapine. Lancet 346 909
Eastwood SL, Burnet PWJ, Harrison PJ (1995) Altered synaptophysin expression as a marker of synaptic pathology in schizophrenia. Neuroscience66 309-319
Burnet PWJ, Mead A, Eastwood SL, Lacey K, Harrison PJ, Sharp TS (1995) Differential effects of ECS on 5-HT1A and 5-HT2A receptor expression. Neuroreport 6 901-904
Burnet PWJ, Eastwood SL, Lacey K, Harrison PJ (1995) The distribution of 5-HT1A and 5-HT2A receptor mRNAs in human brain. Brain Research 676 157-168
Eastwood SL, McDonald B, Burnet PWJ, Beckwith J, Kerwin RW, Harrison PJ (1995) Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluR1 and GluR2 in medial temporal lobe neurons in schizophrenia. Molecular Brain Research 29 211-223
Zaidel DW, Esiri MM, Eastwood SL, Harrison PJ (1995) Asymmetrical hippocampal circuitry and schizophrenia. Lancet 345 656-657
Peer-reviewed reviews and editorials
Harrison PJ, Geddes JR (1995) Molecules, mice, and meta-analyses. Lancet 346 (suppl.) 19
Harrison PJ (1995) Schizophrenia: the misunderstood disease. Psychology Review 2 2-7
Harrison PJ (1995) Another gene found for Alzheimer's disease. Lancet 346 693
Harrison PJ (1995) S182: from worm sperm to Alzheimer's disease. Lancet 346 388
Harrison PJ (1995) On the neuropathology of schizophrenia and its dementia: Neurodevelopmental, neurodegenerative, or both? Neurodegeneration 4 1-12
Chapters
Harrison PJ (1995) Cerebral asymmetry. In Gray's Anatomy, 38th edition (ed Williams PL), Churchill Livingstone, Edinburgh, 1183-1186.
Harrison PJ (1995) In vitro brain imaging: techniques for studying and localizing the pathogenesis of psychiatric diseases. In Neurobiology and Psychiatry, volume 3, ed Kerwin RW. Cambridge University Press, Cambridge, pp157-174
Harrison PJ, Pearson RCA (1995) Principles and practice of in situ hybridization histochemistry in neuropsychiatric research. In Molecular Neuropathology, eds Roberts GW, Polak JM. Cambridge University Press, Cambridge, pp38-60
1994
Data papers
Procter AW, Francis PT, Holmes C, Webster MT, Qume M, Stratmann GC, Doshi R, Mann DM, Harrison PJ, Pearson RCA, Bowen DM (1994) APP isoforms show correlations with neurones but not with glia in human brain. Acta Neuropathologica (Berlin) 88 545-552
Burnet PWJ, Eastwood SL, Harrison PJ (1994) Detection and quantitation of 5-HT1A and 5-HT2A receptor mRNAs in human hippocampus using a reverse transcriptase-polymerase chain reaction (RT-PCR) technique and their correlation with age and binding site densities. Neuroscience Letters 178 85-89
Eastwood SL, Story P, Burnet PWJ, Heath P, Harrison PJ (1994) Differential changes in glutamate receptor subunit messenger RNAs in rat brain after haloperidol treatment. Journal of Psychopharmacology 8 196-203
Eastwood SL, Burnet PWJ, Beckwith J, Kerwin R, Harrison PJ (1994) AMPA glutamate receptors and their flip and flop mRNAs in human hippocampus. Neuroreport 5 1325-1328
Eastwood SL, Burnet PWJ, McDonald B, Clinton J, Harrison PJ (1994) Synaptophysin gene expression in human brain: a quantitative in situ hybridization and immunocytochemical study. Neuroscience 59 881-892
Eastwood SL, Burnet PWJ, Harrison PJ (1994) Striatal synaptophysin expression and haloperidol-induced synaptic plasticity. Neuroreport 5 677-680
Harrison PJ, Barton AJL, Procter AW, Bowen DM, Pearson RCA (1994) The effects of Alzheimer's disease, other dementias and premorten course upon amyloid ß precursor protein messenger RNAs in frontal cortex. Journal of Neurochemistry 62 635-644
Peer-reviewed reviews and editorials
Harrison PJ, Everall IP, Catalan J (1994) Is homosexual behaviour hard-wired? Sexual orientation and brain structure. [Editorial] Psychological Medicine 24 811-816
Harrison PJ, Burnet PWJ (1994) Antisense as an explanatory, experimental and therapeutic tool for psychiatric disorders. [Editorial] Psychological Medicine 24 275-279
Harrison PJ (1994) Molecules and minds. [Anonymous Editorial] Lancet 343 681-682
Chapters
Harrison PJ, Eastwood SL, Kerwin RW (1994) Gene expression in Down's syndrome, Parkinson's disease and schizophrenia. In Regulation of Gene Expression and Brain Function (ed Harrison PJ). Springer-Verlag, Berlin, pp57-64
Harrison PJ (1994) Expression of the ß-amyloid precursor protein gene and the pathogenesis of Alzheimer's disease. In Regulation of Gene Expression and Brain Function, op cit., pp47-56.
Harrison PJ (1994) Gene expression in the brain. In Regulation of Gene Expression and Brain Function, op cit., pp. 1-3
Books
Harrison PJ (1994) Regulation of Gene Expression and Brain Function. Volume 6 of Basic and Clinical Aspects of Neuroscience (Series editors Weil C, Muller O, Thorner E). Springer-Verlag: Berlin Heidelberg
1993
Data papers
Harrison PJ, Procter AW, Exworthy T, Roberts GW, Najlerahim A, Barton AJL, Pearson RCA (1993) Heat shock protein (hsx70) mRNA expression in human brain: effects of neurodegenerative disease and agonal state. Neuropathology and Applied Neurobiology 19 10-21
Peer-reviewed reviews and editorials
Harrison PJ (1993) Antisense: Into the brain [Editorial] Lancet 342 255-256
Harrison PJ (1993) Alzheimer's disease and chromosome 14. Different gene, same process? British Journal of Psychiatry 163 2-5
Barton AJL, Pearson RCA, Najlerahim A, Harrison PJ (1993) Pre and postmortem influences on brain RNA. Journal of Neurochemistry 61 1-11
Chapters
Harrison PJ (1993) Effects of neuroleptics on neuronal and synaptic structure. In Antipsychotic Drugs and their Side Effects, ed.Barnes TRE. Academic Press,London,pp99-110
1992
Peer-reviewed reviews and editorials
Harrison PJ, Roberts GW (1992) How now mad cow? [Editorial] British Medical Journal 304 929-930
Harrison PJ (1992) Conceptual analyses of psychiatric languages: phenomenology, psychosis and classification. Current Opinion in Psychiatry 5 727-731
Chapters
Pearson RCA, Barton AJL, Heath PR, Harrison PJ (1992) Changes in messenger RNA in dementia. In Neurodegeneration, eds. Hunter AJ, Clark M. Academic Press, London, pp151-166
1991
Data papers
Harrison PJ, McLaughlin D, Kerwin RW (1991) Decreased hippocampal expression of a glutamate receptor gene in schizophrenia. Lancet 337 450-452
Harrison PJ, Barton AJL, Najlerahim A, McDonald B, Pearson RCA (1991) Regional and neuronal reductions of polyadenylated messenger RNA in Alzheimer's disease. Psychological Medicine 21 855-866
Harrison PJ, Barton AJL, Pearson RCA (1991) Expression of amyloid beta-protein mRNAs in familial Alzheimer's disease. Neuroreport 2 152-154
Harrison PJ, Barton AJ, McDonald B, Pearson RCA (1991) Alzheimer's disease: specific increases in a G protein subunit (Gs) mRNA in hippocampal and cortical neurons. Molecular Brain Research 10 71-81
Harrison PJ, Procter AW, Barton AJL, Lowe S, Najlerahim A, Bertolucci P, Bowen DM, Pearson RCA (1991) Terminal coma affects messenger RNA detection in post mortem human temporal cortex. Molecular Brain Research 9 161-164
Harrison PJ, Barton AJL, Najlerahim A, McDonald B, Pearson RCA (1991) Increased muscarinic receptor messenger RNA in Alzheimer's disease temporal cortex demonstrated by in situ hybridization histochemistry. Molecular Brain Research 9 15-21
Peer-reviewed reviews and editorials
Harrison PJ (1991) Alzheimer's disease and the ß amyloid gene. British Medical Journal 302 1478-1479
Harrison PJ, Roberts GW (1991) `Life, Jim, but not as we know it'? Transmissible dementias and the prion protein. British Journal of Psychiatry 158 457-470
Harrison PJ (1991) Are mental states a useful concept? Neurophilosophical influences on phenomenology and psychopathology. Journal of Nervous and Mental Disease 179 309-316
Harrison PJ, Mullan MJ (1991) Alzheimer's disease: the significance of a ß-amyloid precursor protein gene mutation. Current Opinion in Neurology and Neurosurgery 4 908-913
Harrison PJ (1991) Searching for the cause of Alzheimer's disease. Psychiatric Bulletin 15 346-347
Harrison PJ (1991) Reading about: Neuroscience. British Journal of Psychiatry 159 891-893
Harrison PJ (1991) Books Reconsidered: Karl Jaspers' General Psychopathology: A trainee's view. British Journal of Psychiatry 159 300-302. Expanded version in The Book of Psychiatric Books, eds. Crown S, Freeman H. Jason Aronson: Northvale, New Jersey, 1994, pp.24-32.
1986-1990
Data Papers
Harrison PJ, Barton AJL, Najlerahim A, Pearson RCA (1990) Distribution of a kainate/AMPA receptor mRNA in normal and Alzheimer brain. Neuroreport 1 149-152
Barton AJL, Harrison PJ, Najlerahim A, Heffernan J, McDonald B, Robinson JR, Davies DC, Harrison WJ, Mitra P, Hardy JA, Pearson RCA (1990) Increased tau messenger RNA in Alzheimer's disease hippocampus. American Journal of Pathology 137 497-502
Najlerahim A, Harrison PJ, Barton AJL, Heffernan J, Pearson RCA (1990) Distribution of messenger RNAs encoding the enzymes glutaminase, aspartate aminotransferase and glutamic acid decarboxylase in rat brain. Molecular Brain Research 7 317-333
Najlerahim A, Barton A, Harrison PJ, Heffernan J, Pearson RCA (1989) Messenger RNA encoding the D2 dopaminergic receptor detected by in situ hybridization histochemistry in rat brain. FEBS Letters 255 335-339
Harrison PJ, Strangeway P, McCann J, Catalan J (1989) Paedophilia and hyperprolactinaemia. British Journal of Psychiatry 155 847-848
Harrison PJ, Mellers JC (1988) The spectrum of dysmorphophobia: case report and review. British Journal of Clinical and Social Psychiatry 6 36-39
Harrison PJ, Day A (1988) What do trainee psychiatrists actually read? Psychiatric Bulletin 12 530-531
Peer-reviewed reviews and editorials
Harrison PJ, Pearson RCA (1990) In situ hybridization histochemistry and the study of gene expression in the human brain. Progress in Neurobiology 34 271-312
Harrison PJ (1990) Neurodegeneration and the nose. Clinical Otolaryngology 15 279-281
Harrison PJ, Pearson RC (1989) Gene expression and mental disease. Psychological Medicine 19 813-819
Harrison PJ, Pearson RC (1989) Olfaction and psychiatry. British Journal of Psychiatry 155 822-828
Harrison PJ (1988) The effects of deafness on musical composition. Journal of the Royal Society of Medicine 81 598-601
Harrison PJ (1986) The pathogenesis of Alzheimer's disease - beyond the cholinergic hypothesis. Journal of the Royal Society of Medicine 79 347-351
